Nintedanib (BIBF 1120)

656247-17-5

methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate

Vargatef

Tyrosine Kinase FGFR Tyrosine Kinase PDGFR Tyrosine Kinase VEGFR

0.9722

A solid

insoluble in H2O; insoluble in EtOH; ≥5.34 mg/mL in DMSO

CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)NC(=C3C4=C(C=C(C=C4)C(=O)OC)NC3=O)C5=CC=CC=C5

C31H33N5O4

539.62

Blue ice

Store at -20°C.