Afatinib (BIBW2992)

439081-18-2

(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide

JAK STAT Signaling EGFR Tyrosine Kinase EGFR Tyrosine Kinase HER2

0.9883

A solid

≥24.3 mg/mL in DMSO; insoluble in H2O; ≥42.1 mg/mL in EtOH with ultrasonic

CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

C24H25ClFN5O3

485.94

Blue ice

Store at -20°C.