Regorafenib

755037-03-7

4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide

BAY 73-4506

Apoptosis c-RET Tyrosine Kinase c-RET Tyrosine Kinase PDGFR Tyrosine Kinase VEGFR

0.9946

A solid

≥25.04 mg/mL in DMSO; insoluble in H2O; ≥6.25 mg/mL in EtOH with ultrasonic

O=C(NC)C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C(F)=C2)=CC=N1

C21H15ClF4N4O3

482.82

Blue ice

Desiccate at -20°C.