SN-38 glucuronide

SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer[1][2][3].

Product Specifications

CAS Number

[121080-63-5]

Product Name Alternative

SN-38G

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sn-38-glucuronide.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 2.5 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : 6.25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1OCC2=C(C=C(C3=NC4=CC=C(O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O5)C=C4C(CC)=C3C6)N6C2=O)[C@@]1(O)CC

Molecular Formula

C28H28N2O11

Molecular Weight

568.53

Precautions

H301, H311, H331

References & Citations

[1]Pellock SJ, et al. Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018;293 (48) :18559-18573.|[2]Atasilp C, et al. Determination of irinotecan, SN-38 and SN-38 glucuronide using HPLC/MS/MS: Application in a clinical pharmacokinetic and personalized medicine in colorectal cancer patients. J Clin Lab Anal. 2018 Jan;32 (1) :e22217.|[3]Wallace BD, et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science. 2010 Nov 5;330 (6005) :831-5.|[4]Ohtsuka K, et al. Intracellular conversion of irinotecan to its active form, SN-38, by native carboxylesterase in human non-small cell lung cancer[J]. Lung Cancer, 2003, 41 (2) : 187-198.