Ponatinib (AP24534)
pan-BCR-ABL inhibitor,multi-kinase inhibitor
Product Specifications
CAS Number
943319-70-8
Product Name Alternative
3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
Field of Research
TGF-β Smad Signaling Bcr-Abl Tyrosine Kinase Bcr-Abl Tyrosine Kinase FGFR Tyrosine Kinase FLT3 Tyrosine Kinase PDGFR Tyrosine Kinase VEGFR
Purity
0.9992
Form
A solid
Solubility
≥53.3 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
Smiles
CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Molecular Formula
C29H27F3N6O
Molecular Weight
532.56
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.
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