VX-680 (MK-0457,Tozasertib)

639089-54-6

N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide

Cell Cycle Checkpoint Aurora Kinase Chromatin Epigenetics Aurora Kinase

0.9993

A solid

≥23.25 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5

C23H28N8OS

464.59

Blue ice

Store at -20°C.