Thiazovivin
Thiazovivin is a potent ROCK inhibitor, which can protect human embryonic stem cells. Thiazovivin improves the efficiency of iPSC generation.
Product Specifications
CAS Number
1226056-71-8
UNSPSC
12352005
Hazard Statement
H302
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Thiazovivin.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=C(C1=CSC(NC2=NC=NC=C2)=N1)NCC3=CC=CC=C3
Molecular Formula
C15H13N5OS
Molecular Weight
311.36
Precautions
H302
References & Citations
[1]Xu Y, et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A. 2010 May 4;107 (18) :8129-34.|[2]Park S, et al. Thiazovivin, a Rho kinase inhibitor, improves stemness maintenance of embryo-derived stem-like cells under chemically defined culture conditions in cattle. Anim Reprod Sci. 2015 Oct;161:47-57.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK
Available Sizes
Frequently Asked Questions
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