Thiazovivin

Thiazovivin is a potent ROCK inhibitor, which can protect human embryonic stem cells. Thiazovivin improves the efficiency of iPSC generation.

Product Specifications

CAS Number

[1226056-71-8]

UNSPSC

12352005

Hazard Statement

H302

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Thiazovivin.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : ≥ 30 mg/mL

Smiles

O=C(C1=CSC(NC2=NC=NC=C2)=N1)NCC3=CC=CC=C3

Molecular Formula

C15H13N5OS

Molecular Weight

311.36

Precautions

H302

References & Citations

[1]Xu Y, et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A. 2010 May 4;107 (18) :8129-34.|[2]Park S, et al. Thiazovivin, a Rho kinase inhibitor, improves stemness maintenance of embryo-derived stem-like cells under chemically defined culture conditions in cattle. Anim Reprod Sci. 2015 Oct;161:47-57.