Go 7874
Go 7874 is a protein kinase C (PKC) inhibitor. Go 7874 mediated neuroprotection against LPS/IFNg-induced neuronal cell death in an immune-mediated neurotoxicity model, not through PKC activity. In contrast, the neuroprotective mechanism of Go 7874 involves inhibition of inducible nitric oxide synthase (iNOS) gene expression, followed by reduced nitric oxide (NO) production[1].
Product Specifications
CAS Number
[153207-86-4]
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/go-7874.html
Smiles
O=C1NC(C2=C1C3=C(N(C4=C3C=C(C=C4)OC)CC(CN(C)C)O)C5=C2C6=C(C=CC=C6)N5C)=O
Molecular Formula
C27H26N4O4
Molecular Weight
470.52
References & Citations
[1]The indolocarbazole Go6976 protects neurons from ¨ lipopolysaccharide/interferon-g-induced cytotoxicity in murine neuron/glia co-cultures
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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