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Dabrafenib Mesylate (GSK-2118436)

Inhibitor of BRAF(V600) mutants

Product Specifications

Product Name Alternative

N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;methanesulfonic acid

Sequence

GSK-2118436 Mesylate;GSK2118436 Mesylate;GSK 2118436 Mesylate;GSK 2118436B,Tafinlar,

Field of Research

MAPK Signaling Raf

Purity

0.9978

Form

A solid

Solubility

≥30.75 mg/mL in DMSO; insoluble in H2O; ≥2.74 mg/mL in EtOH with gentle warming and ultrasonic

Smiles

CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F.CS(=O)(=O)O

Molecular Formula

C24H24F3N5O5S3

Molecular Weight

615.67

Shipping Conditions

Blue ice

Storage Conditions

Store at -20°C.

CAS Number

1195768-06-9

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