CO-1686 (AVL-301)

1374640-70-6

N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide

AVL-301;CNX-419; Rociletinib

JAK STAT Signaling EGFR Tyrosine Kinase EGFR

0.9928

A solid

≥27.8 mg/mL in DMSO; insoluble in H2O; ≥4.68 mg/mL in EtOH with gentle warming and ultrasonic

CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC

C27H28F3N7O3

555.55

Blue ice

Store at -20°C.