Trametinib (GSK1120212)

871700-17-3

N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide

Trametinib, GSK-1120212, GSK1120212, Mekinist, JTP74057, JTP-74057

MAPK Signaling MEK1 2

0.9814

A solid

insoluble in H2O; insoluble in EtOH; ≥15.38 mg/mL in DMSO

CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5

C26H23FIN5O4

615.39

Blue ice

Store at -20°C.