ABT-263 (Navitoclax)
Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w
Product Specifications
Product Name Alternative
(R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide
Sequence
Navitoclax,ABT-263,ABT263,ABT 263
Field of Research
Apoptosis Bcl-2 Family
Purity
0.9854
Solubility
≥48.73 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
Smiles
CC(CC1)(C)CC(CN2CCN(C3=CC=C(C(NS(C4=CC=C(N[C@@H](CSC5=CC=CC=C5)CCN6CCOCC6)C(S(C(F)(F)F)(=O)=O)=C4)(=O)=O)=O)C=C3)CC2)=C1C7=CC=C(Cl)C=C7
Molecular Formula
C47H55ClF3N5O6S3
Molecular Weight
974.61
Shipping Conditions
Blue ice
Storage Conditions
Desiccate at -20°C.
CAS Number
923564-51-6
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