Vemurafenib (PLX4032, RG7204)

918504-65-1

N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide

Vemurafenib, Zelboraf, PLX-4032, RG7204, RO5185426

MAPK Signaling MEK1 2 MAPK Signaling Raf

0.9848

A solid

≥24.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F

C23H18ClF2N3O3S

489.93

Blue ice

Store at -20°C.