Cabozantinib (XL184, BMS-907351)

9007-83-4

1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Tyrosine Kinase Axl Tyrosine Kinase c-MET Tyrosine Kinase FLT3

0.986

A solid

≥25.08 mg/mL in DMSO; insoluble in H2O; ≥20.65 mg/mL in EtOH

COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F

C28H24FN3O5

501.51

Blue ice

Store at -20°C.