(S, R, S) -AHPC-PEG1-OTs

(S, R, S) -AHPC-PEG1-OTs is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology.

Product Specifications

Product Name Alternative

VH032-PEG1-OTs; VHL Ligand-Linker Conjugates 2; E3 ligase Ligand-Linker Conjugates 51

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugates-51.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(C([C@@H](NC(COCCOS(C2=CC=C(C)C=C2)(=O)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3

Molecular Formula

C33H42N4O8S2

Molecular Weight

686.84

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.