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Lumiracoxib

Lumiracoxib is a potent, selective and orally active COX-2 inhibitor with a Ki value of 0.06 μM[1]. Lumiracoxib acts as a nonselective NSAID with anti-inflammatory, analgesic and antipyretic activities. Lumiracoxib can be used for osteoarthritis and bone cancer research[1][2].

Product Specifications

CAS Number

[220991-20-8]

Product Name Alternative

COX-189

UNSPSC

12352005

Hazard Statement

H302

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lumiracoxib.html

Purity

99.93

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)CC1=CC(C)=CC=C1NC2=C(F)C=CC=C2Cl

Molecular Formula

C15H13ClFNO2

Molecular Weight

293.72

Precautions

H302

References & Citations

[1]Ronald Esser, et al. Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. Br J Pharmacol. 2005 Feb;144 (4) :538-50.|[2]Alyson Fox, et al. Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. Pain

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

COX-1; COX-2

Available Sizes

Curated Selection

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