BKI-1369
Product Specifications
UNSPSC Description
BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves[1].
Target Antigen
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bki-1369.html
Purity
98.77
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
NC1=C2C(N(CC3CCN(C)CC3)N=C2C4=CC=C5N=C(OCC)C=CC5=C4)=NC=N1
Molecular Weight
417.51
References & Citations
[1]Lee S, et al. Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by <i>Cryptosporidium hominis</i>. Antimicrob Agents Chemother. 2018 Jun 26;62(7).
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121495/BKI-1369-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121495/BKI-1369-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1951431-22-3
Available Sizes
Curated Selection
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