SPP-DM1
Product Specifications
UNSPSC Description
SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP[1].
Target Antigen
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spp-dm1.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCSSC(C)CCC(ON5C(CCC5=O)=O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
Molecular Weight
967.54
References & Citations
[1]Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126491/SPP-DM1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126491/SPP-DM1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
452072-20-7
Available Sizes
Curated Selection
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