AUTAC1
Product Specifications
UNSPSC Description
AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2[1].
Target Antigen
AUTACs; Autophagy
Type
Reference compound
Related Pathways
Autophagy;PROTAC
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/autac1.html
Smiles
CO[C@H]1[C@@]([C@]([C@H]2C/C=C(C)\C)(O2)C)([H])[C@@]3(CO3)CC[C@H]1OC(NCCCOCCOCCOCCCNC([C@@H](NC(C)=O)CSC4=NC5=C(N=C(N)NC5=O)N4CC6=CC=C(F)C=C6)=O)=O
Molecular Weight
931.08
References & Citations
[1]Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-134183/AUTAC1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-134183/AUTAC1-SDS-MedChemExpress.pdf
CAS Number
2241669-09-8
Available Sizes
Curated Selection
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