Lurasidone-d8-1 (hydrochloride)

Lurasidone-d8-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride) . Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride) ) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride) ) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM[1].

Product Specifications

Product Name Alternative

SM-13496-d8-1 (hydrochloride)

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor; Isotope-Labeled Compounds

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

[H][C@]12C[C@@]([H])(CC2)[C@@]3([H])[C@]1([H])C(N(C3=O)C[C@@H]4CCCC[C@H]4CN5C([2H])(C([2H])(N(C([2H])(C5([2H])[2H])[2H])C6=NSC7=C6C=CC=C7)[2H])[2H])=O.Cl

Molecular Formula

C28H29D8ClN4O2S

Molecular Weight

537.19

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4) : 931-937.|[3]Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334 (1) :171-81.