Thalidomide-4-NH-PEG2-COO (t-Bu)

Thalidomide-4-NH-PEG2-COO (t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG2-COO (t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG2-COO (t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

Product Specifications

CAS Number

[2140807-16-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-4-nh-peg2-coo-t-bu.html

Solubility

10 mM in DMSO

Smiles

O=C(OC(C)(C)C)CCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Molecular Formula

C24H31N3O8

Molecular Weight

489.52

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]