CAY10789
Product Specifications
UNSPSC Description
CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1].
Target Antigen
G protein-coupled Bile Acid Receptor 1; Leukotriene Receptor; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis;GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cay10789.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OCC1=CC=CC(OCC2=NC3=CC=CC=C3C=C2)=C1
Molecular Weight
265.31
References & Citations
[1]Fiorillo B, et al. Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64(22):16512-16529.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147086/CAY10789-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147086/CAY10789-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
123226-28-8
Available Sizes
Curated Selection
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