CA/MAO-B-IN-1
CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC50s of 8.8 and 7.0 nM, respectively. CA/MAO-B-IN-1 reveals a human oral absorption of 71.9% through in silico prediction[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ca-mao-b-in-1.html
Concentration
10mM
Purity
98.34
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(COC2=CC(O3)=C(C=C2)C=C(C)C3=O)C=C1)(N)=O
Molecular Formula
C17H15NO5S
Molecular Weight
345.37
References & Citations
[1]Giovannuzzi S, et al., Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction. J Med Chem. 2024 Mar 14;67 (5) :4170-4193.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA; CA II; CA I; CA XII
Available Sizes
Curated Selection
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