CA/MAO-B-IN-1

CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC50s of 8.8 and 7.0 nM, respectively. CA/MAO-B-IN-1 reveals a human oral absorption of 71.9% through in silico prediction[1].

Product Specifications

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ca-mao-b-in-1.html

Concentration

10mM

Purity

98.34

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(COC2=CC(O3)=C(C=C2)C=C(C)C3=O)C=C1)(N)=O

Molecular Formula

C17H15NO5S

Molecular Weight

345.37

References & Citations

[1]Giovannuzzi S, et al., Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction. J Med Chem. 2024 Mar 14;67 (5) :4170-4193.