Pe1b

Pe1b (μ-TrTx-Pe1b) is a selective Nav1.7 inhibitor with an IC50 of 167 nM[1].

Product Specifications

Product Name Alternative

μ-TrTx-Pe1b

UNSPSC

12352209

Target

Sodium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pe1b.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)CCC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(NC(C(NC(C(N[C@H](C(NCC(NC(C(N[C@H]1CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)[C@@H](C)O)=O)=O)CC(O)=O)=O)CC4=CNC5=CC=CC=C45)=O)C(C)C)=O)=O)CC(O)=O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CO)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N7[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CC8=CNC9=CC=CC=C89)=O)CC%10=CNC=N%10)=O)CC%11=CNC%12=CC=CC=C%11%12)=O)CCCCN)=O)CCC7)=O)CO)=O)=O)=O)=O)CC(C)C)=O)CC%13=CNC%14=CC=CC=C%13%14)=O)CC%15=CC=C(O)C=C%15)=O)CCCNC(N)=N)=O)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6CO)=O)CC(C)C)=O)CC%16=CNC=N%16)=O)CCC(O)=O)=O

Molecular Formula

C175H237N47O49S6

Molecular Weight

3975.43

References & Citations

[1]Rupasinghe DB, et al. Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7. Biochem Pharmacol. 2020 Nov;181:114080.