Pe1b
Product Specifications
UNSPSC Description
Pe1b (μ-TrTx-Pe1b) is a selective Nav1.7 inhibitor with an IC50 of 167 nM[1].
Target Antigen
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pe1b.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CCC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(NC(C(NC(C(N[C@H](C(NCC(NC(C(N[C@H]1CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)[C@@H](C)O)=O)=O)CC(O)=O)=O)CC4=CNC5=CC=CC=C45)=O)C(C)C)=O)=O)CC(O)=O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CO)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N7[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CC8=CNC9=CC=CC=C89)=O)CC%10=CNC=N%10)=O)CC%11=CNC%12=CC=CC=C%11%12)=O)CCCCN)=O)CCC7)=O)CO)=O)=O)=O)=O)CC(C)C)=O)CC%13=CNC%14=CC=CC=C%13%14)=O)CC%15=CC=C(O)C=C%15)=O)CCCNC(N)=N)=O)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6CO)=O)CC(C)C)=O)CC%16=CNC=N%16)=O)CCC(O)=O)=O
Molecular Weight
3975.43
References & Citations
[1]Rupasinghe DB, et al. Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7. Biochem Pharmacol. 2020 Nov;181:114080.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5809/Pe1b-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5809/
Clinical Information
No Development Reported
Curated Selection
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