24 (S) -Hydroxycholesterol

24 (S) -Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24 (S) -Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24 (S) -Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].

Product Specifications

CAS Number

[474-73-7]

Product Name Alternative

24S-OHC; 24S-HC; Cerebrosterol

UNSPSC

12352211

Target

Endogenous Metabolite; iGluR; LXR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/24_S_-Hydroxycholesterol.html

Purity

99.75

Solubility

DMSO : 12.5 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic; warming)

Smiles

C[C@H](CC[C@H](O)C(C)C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

Molecular Formula

C27H46O2

Molecular Weight

402.65

References & Citations

[1]Yuki Kimura, et al. Tocopherol suppresses 24 (S) -hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Biochimie. 2018 Oct;153:203-209.|[2]M Shafaati, et al. Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med. 2011 Oct;270 (4) :377-87.|[3]Steven M Paul, et al. The major brain cholesterol metabolite 24 (S) -hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33 (44) :17290-300.|[4]Ishikawa M, et al. 24 (S) -Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure. Sci Rep. 2016 Sep 22;6:33886.