Isoscopoletin

Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2]. Isoscopoletin exhibits anti-inflammatory activity through inhibition of MAPK/NF-κB/STAT/AKT signaling pathway[3].

Product Specifications

CAS Number

[776-86-3]

Product Name Alternative

6-Hydroxy-7-methoxycoumarin

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Akt; ERK; HBV; JNK; NF-κB; p38 MAPK; STAT

Type

Natural Products

Related Pathways

Anti-infection; JAK/STAT Signaling; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/isoscopoletin.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=CC(O)=C(OC)C=C2O1

Molecular Formula

C10H8O4

Molecular Weight

192.17

Precautions

H302, H312, H332

References & Citations

[1]Adams M, et al. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72 (9) :862-4.|[2]Li H, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Med. 2005 Dec;71 (12) :1128-33.|[3]Ruan C, et al., Isoscopoletin inhibits hepatocellular carcinoma cell proliferation via regulating glycolysis-related proteins. PLoS One. 2024 Nov 7;19 (11) :e0310530.|[4]Seo DY, et al., Effect of Isoscopoletin on Cytokine Expression in HaCaT Keratinocytes and RBL-2H3 Basophils: Preliminary Study. Int J Mol Sci. 2024 Jun 24;25 (13) :6908.