kb NB 142-70
Product Specifications
UNSPSC Description
kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.
Target Antigen
PKD
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kb-NB-142-70.html
Solubility
DMSO : 46.67 mg/mL (ultrasonic)
Smiles
O=C1NCCSC2=C1SC3=CC=C(O)C=C32
Molecular Weight
251.32
References & Citations
[1]Lavalle CR, et al. Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. BMC Chem Biol. 2010 May 5;10:5.|[2]James Sinnett-Smith, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15; 306(10): C961-C971.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15528/kb-NB-142-70-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15528/kb-NB-142-70-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1233533-04-4
Available Sizes
Curated Selection
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