Kb NB 142-70

Kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.

Product Specifications

CAS Number

[1233533-04-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

PKD

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kb-NB-142-70.html

Purity

98.02

Solubility

DMSO : 46.67 mg/mL (ultrasonic)

Smiles

O=C1NCCSC2=C1SC3=CC=C(O)C=C32

Molecular Formula

C11H9NO2S2

Molecular Weight

251.32

Precautions

H315, H319, H335

References & Citations

[1]Lavalle CR, et al. Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. BMC Chem Biol. 2010 May 5;10:5.|[2]James Sinnett-Smith, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15; 306 (10) : C961-C971.