Norartocarpetin

Norartocarpetin is a tyrosinase inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC50 value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC50 value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells[1][2].

Product Specifications

CAS Number

[520-30-9]

UNSPSC

12352005

Target

Apoptosis; MAPKAPK2 (MK2) ; Raf; Ras; Tyrosinase

Type

Natural Products

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/norartocarpetin.html

Concentration

10mM

Purity

99.28

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(O)C=C2O)OC3=CC(O)=CC(O)=C13

Molecular Formula

C15H10O6

Molecular Weight

286.24

References & Citations

[1]Zong-Ping Zheng, et al. Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent. Mol Nutr Food Res|[2]Ning Guo, et al. Antiproliferative effects of Norartocarpetin isoflavone in human lung carcinoma cells are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion. J BUON. 2020 Mar-Apr;25 (2) :855-861.