Notum-IN-1
Notum-IN-1 (compound 6b) is an orally active, selective and brain penetrant inhibitor of Notum. Notum-IN-1 blocks the Wnt signaling in vivo in mouse[1].
Product Specifications
CAS Number
[338419-11-7]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/notum-in-1.html
Solubility
10 mM in DMSO
Smiles
OCC1=CN(C2=CC=C(Cl)C(Cl)=C2)N=N1
Molecular Formula
C9H7Cl2N3O
Molecular Weight
244.08
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Willis NJ, et al. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J Med Chem. 2022 May 26;65 (10) :7212-7230.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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