TIQ-A

TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent[1].

Product Specifications

CAS Number

[420849-22-5]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tiq-a.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C3=C1C=CC=C3)C=CS2

Molecular Formula

C11H7NOS

Molecular Weight

201.25

Precautions

H302, H312, H332

References & Citations

[1]Maksimainen MM, et al. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg Med Chem. 2021 Dec 15;52:116511.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP10; PARP14; PARP15; PARP2; TNKS2/PARP5B

Available Sizes

Curated Selection

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