TIQ-A
TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent[1].
Product Specifications
CAS Number
420849-22-5
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tiq-a.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C3=C1C=CC=C3)C=CS2
Molecular Formula
C11H7NOS
Molecular Weight
201.25
Precautions
H302, H312, H332
References & Citations
[1]Maksimainen MM, et al. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg Med Chem. 2021 Dec 15;52:116511.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP10; PARP14; PARP15; PARP2; TNKS2/PARP5B
Available Sizes
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