ABCC6 antibody
Product Specifications
Background
The ATP-binding cassette transporter 6 (ABCC6) gene, also named as MRP6, is a cellular transmembrane protein transporter and belongs to ATP-binding cassette (ABC) family. ABCC6 is an ATP-dependent transporter contains two ATP-binding domains. It is mainly found in the liver, the proximal tubules of the kidneys and the intestines. ABCC6 is involved in a pathway of extracellular nucleotide metabolism and the regulation of tissue calcification. Mutations of ABCC6 leads to pseudoxanthoma elasticum (PXE) which is a rare autosomal recessive disorder. Mutations of ABCC6 can also lead generalized arterial calcification of infancy-2 (GACI2) .
Synonyms
ATP-binding cassette sub-family C member 6|Anthracycline resistance-associated protein|Multi-specific organic anion transporter E (MOAT-E) |Multidrug resistance-associated protein 6|ABCC6|ARA|MRP6
UniProt
O95255
Host
Rabbit
Reactivity
Human
Immunogen
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Target
ABCC6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
165 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC
Immunogen Sequence
1437-1499
Curated Selection
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