ML350
ML350 (CYM50202) is a highly potent OPRK1 antagonist with selectivity and broad biological applications. With IC50 values of 9-16 nM, ML350 shows high selectivity for OPRK1, with selectivity of 219-382-fold and 20-35-fold relative to OPRD1 and OPRM1, respectively. ML350 exhibited favorable characteristics in in vivo pharmacokinetic analysis, including high passive membrane permeability and moderate human plasma protein binding. Extensive screening of ML350 against multiple ion channels, receptors, and transporters showed that it does not have adverse off-target effects[1].
Product Specifications
CAS Number
1565852-90-5
Product Name Alternative
CYM50202
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ml350.html
Smiles
O=C(OC)C1=CC(Br)=CN=C1N2C[C@@H]([C@H](CC2)NC3CCCCC3)O
Molecular Formula
C18H26BrN3O3
Molecular Weight
412.32
References & Citations
[1]Optimization and characterization of an opioid kappa receptor (OPRK1) antagonist
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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