PROTAC ERRα Degrader-1

PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an PROTAC estrogen-related receptor alpha (ERRa) degrader[1].

Product Specifications

CAS Number

[2306388-84-9]

UNSPSC

12352005

Target

Estrogen Receptor/ERR; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-erralpha-degrader-1.html

Purity

98.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CC(N(CC(NCCNC(/C(C#N)=C/C2=CC(OC)=C(OCC3=C(C=C(C(F)(F)F)C=C3)C(F)(F)F)C=C2)=O)=O)CC1)=O)N4[C@@H](C5=CC=C(Cl)C=C5)[C@@H](C6=CC=C(Cl)C=C6)N=C4C7=C(C=C(OC)C=C7)OC(C)C

Molecular Formula

C54H49Cl2F6N7O8

Molecular Weight

1108.91

References & Citations

[1]Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10 (5) :767-772.