EGFR-IN-138
EGFR-IN-138 (compound 19) is a potent EGFR inhibitor, with IC50s of 37, 2.6 and 1.9 nM for Wild-type, L858R and T790M EGFR, respectively[1].
Product Specifications
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-138.html
Smiles
CCC1=NC(C2=CC(NC(C3=C(C(O)=CC=C3)CN4C(C5=C(C4)C=CC=C5)=O)=O)=CC=C2)=C(N1)C6=CC=NC(NC7=C(C=CC(NC(C=C)=O)=C7)OC)=C6
Molecular Formula
C42H37N7O5
Molecular Weight
719.79
References & Citations
[1]Wittlinger F, et, al. Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent "Type V" Kinase Inhibitors. J Med Chem. 2024 Dec 12;67 (23) :21438-21469.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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