EGFR-IN-138
Product Specifications
UNSPSC Description
EGFR-IN-138 (compound 19) is a potent EGFR inhibitor, with IC50s of 37, 2.6 and 1.9 nM for Wild-type, L858R and T790M EGFR, respectively[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-138.html
Smiles
CCC1=NC(C2=CC(NC(C3=C(C(O)=CC=C3)CN4C(C5=C(C4)C=CC=C5)=O)=O)=CC=C2)=C(N1)C6=CC=NC(NC7=C(C=CC(NC(C=C)=O)=C7)OC)=C6
Molecular Weight
719.79
References & Citations
[1]Wittlinger F, et, al. Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent "Type V" Kinase Inhibitors. J Med Chem. 2024 Dec 12;67(23):21438-21469.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169428/EGFR-IN-138-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169428/
Clinical Information
No Development Reported
Curated Selection
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