9-Hydroxyoctadecanoic acid
9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ∼66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity[1].
Product Specifications
CAS Number
[3384-24-5]
Product Name Alternative
9-Hydroxystearic acid; 9-HSA
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
HDAC
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/9-hydroxyoctadecanoic-acid.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(CCCCCCCC(CCCCCCCCC)O)O
Molecular Formula
C18H36O3
Molecular Weight
300.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Calonghi N, et al. Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer. J Lipid Res. 2005 Aug;46 (8) :1596-603.|[2]Calonghi N, et al. 9-Hydroxystearic acid upregulates p21 (WAF1) in HT29 cancer cells. Biochem Biophys Res Commun. 2004 Jan 30;314 (1) :138-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HDAC1
Available Sizes
Curated Selection
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