Pan-RAS-IN-5
Product Specifications
UNSPSC Description
Pan-RAS-IN-5 (compound 7A) is a molecular glues that can form a ternary complex with the proteins cyclophilin A (CYPA) and RAS (ON). The formation of the ternary complex can block the binding of RAS downstream of RAF and has anti-tumor effects[1].
Target Antigen
Cyclophilin; Molecular Glues; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation;MAPK/ERK Pathway;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-ras-in-5.html
Smiles
O=C([C@@H](NC([C@H]1C[C@@H]1C)=O)CC2=NC(C3=CC(C(CC(C)(COC4=O)C)=[C@@]([C@@]5=C([C@@H](OC)C)N=CC(N6CCN(C)CC6)=C5)N7CC)=C7C=C3)=CS2)N8N[C@H]4C9CC8C9
Molecular Weight
823.06
References & Citations
[1]Medshine Discovery Inc. Macrocyclic derivative and use thereof. World Intellectual Property Organization, WO2024067857 A1 2024-04-04
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162536/Pan-RAS-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162536/
Clinical Information
No Development Reported
Curated Selection
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