Pan-RAS-IN-5
Pan-RAS-IN-5 (compound 7A) is a molecular glues that can form a ternary complex with the proteins cyclophilin A (CYPA) and RAS (ON) . The formation of the ternary complex can block the binding of RAS downstream of RAF and has anti-tumor effects[1].
Product Specifications
UNSPSC
12352005
Target
Cyclophilin; Molecular Glues; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-ras-in-5.html
Smiles
O=C([C@@H](NC([C@H]1C[C@@H]1C)=O)CC2=NC(C3=CC(C(CC(C)(COC4=O)C)=[C@@]([C@@]5=C([C@@H](OC)C)N=CC(N6CCN(C)CC6)=C5)N7CC)=C7C=C3)=CS2)N8N[C@H]4C9CC8C9
Molecular Formula
C45H58N8O5S
Molecular Weight
823.06
References & Citations
[1]Medshine Discovery Inc. Macrocyclic derivative and use thereof. World Intellectual Property Organization, WO2024067857 A1 2024-04-04
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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