8-Iso-15-keto prostaglandin F2β

8-ISo-15-keto prostaglandin F2β is a potential metabolite of 8-Iso PGF2β via the 15-hydroxy-PG dehydrogenase pathway. 8-iso PGF2β constricts pulmonary veins in dogs and pigs[1][2].

Product Specifications

CAS Number

[1621482-36-7]

UNSPSC

12352211

Hazard Statement

H225-H319-H336-H360

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/8-iso-15-keto-prostaglandin-f2β.html

Solubility

10 mM in DMSO

Smiles

OC(CCC/C=C\C[C@H]1[C@H]([C@@H](C[C@H]1O)O)/C=C/C(CCCCC)=O)=O

Molecular Formula

C20H32O5

Molecular Weight

352.47

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Janssen LJ, et al. Vasoconstrictor actions of isoprostanes via tyrosine kinase and Rho kinase in human and canine pulmonary vascular smooth muscles. Br J Pharmacol. 2001 Jan;132 (1) :127-34.|[2]Janssen LJ, et al. Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature. J Pharmacol Exp Ther. 2002 Jun;301 (3) :1060-6.