MG-B-28
MG-B-28 is an inhibitor of BTLA-HVEM with an IC50 value of 906 nM. MG-B-28 promotes T-cell activation in a dose-dependent manner by blocking the BTLA-HVEM interaction[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mg-b-28.html
Smiles
COC1=CC=C([C@@H](C#N)N2CCN(C(C(C3=C4C=CC=C3)=NN(C5=CC=CC=C5)C4=O)=O)CC2)C=C1
Molecular Formula
C28H25N5O3
Molecular Weight
479.53
References & Citations
[1]Abdel-Rahman S A, et al. Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints[J]. Science Advances, 2024, 10 (42) : eadq5540.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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