Telomeric G4s ligand 1
Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells[1].
Product Specifications
CAS Number
3047091-81-3
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; G-quadruplex
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/telomeric-g4s-ligand-1.html
Smiles
CN(CCN(C)C)C1=CC=C(C2=C(C3=CC=C(N(C)CCN(C)C)C=C3)N=C(C=CC(C(F)(F)F)=C4)C4=N2)C=C1
Molecular Formula
C31H37F3N6
Molecular Weight
550.66
References & Citations
[1]Jia-Xin Wang, et al. Novel quinoxaline analogs as telomeric G-quadruplex ligands exert antitumor effects related to enhanced immunomodulation. Eur J Med Chem. 2024 Aug 5:274:116536.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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