Prostaglandin F3α

Prostaglandin F3α (PGF3α) is an eicosapentaenoic acid (EPA) -derived bioactive lipid mediator that has anti-cancer and anti-inflammatory effects. Prostaglandin F3α is a substrate of ABCC4 with a Km of 12.1 μM. Prostaglandin F3α can be used for the research of diabetes[1][2].

Product Specifications

CAS Number

[745-64-2]

Product Name Alternative

PGF3α

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/prostaglandin-f3α.html

Solubility

10 mM in DMSO

Smiles

OC(CCC/C=C\C[C@@H]1[C@H]([C@@H](C[C@@H]1O)O)/C=C/[C@@H](O)C/C=C\CC)=O

Molecular Formula

C20H32O5

Molecular Weight

352.47

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Tanaka N, et al. Transport of eicosapentaenoic acid-derived PGE₃, PGF (3α), and TXB₃ by ABCC4. PLoS One. 2014 Oct 2;9 (10) :e109270.|[2]Sailaja Devi MM, et al. Effect of prostaglandins against alloxan-induced diabetes mellitus. Prostaglandins Leukot Essent Fatty Acids. 2006 Jan;74 (1) :39-60.