PAMP-12 (unmodified) (TFA)

PAMP-12 (unmodified) TFA is a potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM) . PAMP-12 (unmodified) is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells[1].

Product Specifications

UNSPSC

12352209

Target

Mas-related G-protein-coupled Receptor (MRGPR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pamp-12-unmodified-tfa.html

Solubility

10 mM in DMSO

Smiles

N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O.O=C(C(F)(F)F)O

Molecular Formula

C79H119F3N24O17

Molecular Weight

1733.94

References & Citations

[1]Kamohara M, et al. Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem Biophys Res Commun. 2005;330 (4) :1146-1152.