Mubritinib
Mubritinib (TAK-165) is a potent and selective EGFR2/HER2 inhibitor with an IC50 of 6 nM.
Product Specifications
CAS Number
[366017-09-6]
Product Name Alternative
TAK-165
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Mubritinib.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC(C1=CC=C(/C=C/C2=NC(COC3=CC=C(CCCCN4N=NC=C4)C=C3)=CO2)C=C1)(F)F
Molecular Formula
C25H23F3N4O2
Molecular Weight
468.47
Precautions
H302, H315, H320, H335
References & Citations
[1]Nagasawa J, et al. Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo. Int J Urol. 2006 May;13 (5) :587-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
ErbB2/HER2
Available Sizes
Curated Selection
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