Figitumumab
Figitumumab (CP-751871) is a potent and fully human monoclonal anti–insulin-like growth factor 1 receptor (IGF1R) antibody. Figitumumab prevents IGF1 from binding to IGF1R with an IC50 of 1.8 nM[1].
Product Specifications
CAS Number
[943453-46-1]
Product Name Alternative
CP-751871
UNSPSC
12352203
Target
IGF-1R
Type
Inhibitory Antibodies
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/figitumumab.html
Purity
99.80
Solubility
10 mM in DMSO
Smiles
[Figitumumab]
Molecular Weight
(144.5 kDa)
References & Citations
[1]Pavlicek A, et al. Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871) . Mol Cancer Ther. 2013 Dec;12 (12) :2929-39.|[2]Cohen BD, et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res. 2005 Mar 1;11 (5) :2063-73.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2
Available Sizes
Curated Selection
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