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Calcitriol

Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

Product Specifications

CAS Number

32222-06-3

Product Name Alternative

1,25-Dihydroxyvitamin D3

UNSPSC

12352211

Hazard Statement

H300+H310+H330, H372

Target

Drug Metabolite; Endogenous Metabolite; VD/VDR

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Calcitriol.html

Purity

99.94

Solubility

DMSO : 110 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](CCCC(C)(O)C)C)CCC/2)[H])O)O

Molecular Formula

C27H44O3

Molecular Weight

416.64

Precautions

H300+H310+H330, H372

References & Citations

[1]Wang G, et al. Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression. Oncol Res. 2014;22 (5-6) :301-9.|[2]Santos-Martínez N, et al. Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: a potential new therapeutic approach. BMC Cancer. 2014 Mar 29;14:230.|[3]Dong J, et al. Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor. Kidney Int. 2013 Jul;84 (1) :54-63.|[4]Chou CL, et al. Beneficial effects of calcitriol on hypertension, glucose intolerance, impairment of endothelium-dependent vascular relaxation, and visceral adiposity in fructose-fed hypertensive rats. PLoS One. 2015 Mar 16;10 (3) :e0119843.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Human Endogenous Metabolite

Available Sizes

Frequently Asked Questions

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