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(+) -Usnic acid (Standard)

(+) -Usnic acid (Standard) is the analytical standard of (+) -Usnic acid. This product is intended for research and analytical applications. (+) -Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+) -Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity[1]. (+) -Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium[2].

Product Specifications

CAS Number

7562-61-0

UNSPSC

12352005

Target

Autophagy; Bacterial; mTOR; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Autophagy; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/plus-usnic-acid-standard.html

Smiles

O=C([C@@]1(C)C(OC2=C(C(C)=O)C(O)=C(C)C(O)=C12)=C3)C(C(C)=O)C3=O

Molecular Formula

C18H16O7

Molecular Weight

344.32

References & Citations

[1]Ebrahim HY, et al. Usnic Acid Benzylidene Analogues as Potent Mechanistic Target of Rapamycin Inhibitors for the Control of Breast Malignancies. J Nat Prod. 2017 Apr 28;80 (4) :932-952.|[2]Francolini I, et al. Usnic acid, a natural antimicrobial agent able to inhibit bacterial biofilm formation on polymer surfaces. Antimicrob Agents Chemother. 2004;48 (11) :4360-4365.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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