ST2 Mouse Monoclonal Antibody [PSH01-69]
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
Interleukin-1 receptor-like 1 Protein ST2 IL1RL1 DER4 ST2 T1
Swiss Prot
Q01638 Human
Cellular Locus
Cell membrane, Membrane, Secreted.
Host
Mouse
Species Reactivity
Human
Immunogen
Recombinant protein within human ST2 aa 19-328 (Extracellular).
Isotype
IgG1
Clone
PSH01-69
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
HeLa transfected with FLAG-tagged ST2 cell lysate, HeLa overexpress with ST2.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:100 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 63.4 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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