NSCLC-IN-1
NSCLC-IN-1 (Compound A10-2) induces mitophagy and ferroptosis through targeting transmembrane BAX inhibitor motif containing 6 (TMBIM6) . NSCLC-IN-1 induces mitochondrial Ca2+ imbalance, leading to mitochondrial damage. NSCLC-IN-1 reduces intracellular glutathione (GSH), increases the accumulation of lipid peroxides (LPO) and malondialdehyde (MDA) content. NSCLC-IN-1 is a potent anti-NSCLC agent[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis; Mitophagy
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsclc-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(O[C@H]1C(C)=C[C@]23[C@]1(O)[C@H](O)C(COC(C4=CC=C([N+]([O-])=O)C=C4)=O)=CC(C3=O)([H])[C@@]5([H])[C@@](C5(C)C)(OC(CCCCCCCCCCC)=O)C[C@H]2C)C6=CC=C([N+]([O-])=O)C=C6
Molecular Formula
C46H56N2O13
Molecular Weight
844.94
References & Citations
[1]Wang Y, et al. 13-oxyingenol dodecanoate derivatives induce mitophagy and ferroptosis through targeting TMBIM6 as potential anti-NSCLC agents. Eur J Med Chem. 2024 Apr 15;270:116312.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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