PSN632408

PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively) . PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders[1][2].

Product Specifications

CAS Number

[857652-30-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

GPR119

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/PSN632408.html

Purity

99.30

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(OC(C)(C)C)N1CCC(CC1)OCC2=NC(C3=CC=NC=C3)=NO2

Molecular Formula

C18H24N4O4

Molecular Weight

360.41

Precautions

H315, H319, H320

References & Citations

[1]Gao J, et al. Stimulating beta cell replication and improving islet graft function by GPR119 agonists. Transpl Int. 2011;24 (11) :1124-1134.|[2]Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3 (3) :167-175.